Here are some ideas/questions to consider. Please discuss and add your own.
LocationWould Anaksha prefer a summer or winter holiday? That would affect the venue. For summer, it could be a tropical island. For winter, it could be a ski resort. The countryside lodge (as seen in the other topic) could be suitable for either summer or winter.
(By the way, these suggestions are based Anaksha choosing something fairly high-end since she is rich. For some reason she doesn't look right hitchhiking with a backpack

)
PeopleWho will be on the holiday? Will Anaksha go alone, or with her adopted family? Will D get an invitation?
Also, I still strongly hope for a special appearance by Creepy Guy since there is just too much comedy potential here

I know he doesn't seem wealthy, but he could have won the trip on a scratch card or something.
CrimeWhat will the crime be? In the other topic we talked about drug deals. I have also heard about sex slavery using immigrants; maybe that could be incorporated as an underground tourist attraction?
AssassinationHow might Anaksha kill the criminals without using a gun? This is probably the main attraction of such a game. The mission could be based on finding a way to poison their food, or putting a bomb in their room. Anaksha would have to search for the materials required to create a poison/bomb, and then look for ways to sneak into the right places inside the hotel etc..